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A Phenotype Based AI Pipeline Outperforms Human Experts in Differentially Diagnosing Rare Diseases Using EHRs

Xiaohao Mao, Yu Huang, Ye Jin, Lun Wang, Xuanzhong Chen, Honghong Liu, Xinglin Yang, Haopeng Xu, Xiaodong Luan, Ying Xiao, Siqin Feng, Jiahao Zhu, Xuegong Zhang, Rui Jiang, Shuyang Zhang, Ting Chen

January 2025 Npj Digital Medicine

Machine learning--enabled virtual screening indicates the anti-tuberculosis activity of aldoxorubicin and quarfloxin with verification by molecular docking, molecular dynamics simulations, and biological evaluations

Si Zheng, Yaowen Gu, Yuzhen Gu, Yelin Zhao, Liang Li, Min Wang, Rui Jiang, Xia Yu, Ting Chen, Jiao Li

January 2025 Briefings in Bioinformatics

Clinical phenotyping of septic shock with latent profile analysis: A retrospective multicenter study

Guanghao Liu, Ruoqiong Wu, Jun He, Yichang Xu, Li Han, Yingying Yu, Haibo Zhu, Yehan Guo, Hao Fu, Ting Chen, others

January 2025 Journal of Critical Care

Differentiation of light chain cardiac amyloidosis and hypertrophic cardiomyopathy by ensemble machine learning-based radiomic analysis of cardiac magnetic resonance

Shuyuan Zhang, Yubo Guo, Yuze Gao, Ming Wu, Shengsheng Zhuang, Xiao Li, Ting Chen, Jian Li, Zhuang Tian, Yining Wang, others

January 2025 Orphanet Journal of Rare Diseases

Dual-task deep learning model for prediction of medulloblastoma molecular subgroups with preoperative brain MRI

Lingxiao Luo, Xu An, Jing Zhang, Wentao Zhou, Xiaobin Zhao, Hanguang Zhao, Yongji Tian, Ting Chen, Fu Zhao

January 2025 La radiologia medica

Escaping the drug-bias trap: using debiasing design to improve interpretability and generalization of drug-target interaction prediction

Peidong Zhang, Jianzhu Ma, Ting Chen

January 2025 IEEE Transactions on Computational Biology and Bioinformatics

Exploration of the clonal evolution and construction of the tumor clonal evolution rate as a prognostic indicator in metastatic breast cancer

Dan Lv, Bo Lan, Qihan Guo, Zongbi Yi, Haili Qian, Yanfang Guan, Xuenan Peng, Ting Chen, Fei Ma

January 2025 BMC medicine

Global diversity and distribution of antibiotic resistance genes in human wastewater treatment systems

Congmin Zhu, Linwei Wu, Daliang Ning, Renmao Tian, Shuhong Gao, Bing Zhang, Jianshu Zhao, Ya Zhang, Naijia Xiao, Yajiao Wang, others

January 2025 Nature communications

Metabolic acclimation to warming links unexpected immune activation and sexual dimorphism attenuation in Xenopus tropicalis

Jiaying Li, Jiahao Zhu, Ayi Budian, Yiwei Zeng, Shouhong Wang, Yuzhou Gong, Xungang Wang, Longhui Zhao, Na Tang, Si Zheng, others

January 2025 Communications Biology

MyClone: rapid and precise reconstruction of clonal population structures for tumors

Qihan Guo, Dan Lv, Bo Lan, Haili Qian, Fei Ma, Ting Chen

January 2025 BMC bioinformatics